Dendritic Cells and Elite Controllers

Research Overview

The Yu lab studies HIV viruses in diverse groups of participants to investigate possible ways in which the immune system can recognize and combat HIV infection. We study specific types of disease response, like those found in “elite controllers,” people whose immune systems can handle prolonged HIV infection. The lab also looks at how certain innate immune responses, targeting a broad spectrum of pathogens, can be trained to support other immune responses to HIV.

The Yu lab combines basic science immunology with clinical and translational perspectives for improving clinical treatment options for viral infectious disease. Recently, we investigated the proviral reservoirs of “elite controllers,” HIV-1 infected individuals capable of drug-free control of HIV-1 replication despite the presence of a replication-competent viral reservoir. Our research includes the role of dendritic cells and their immunoregulatory functions for generating and fine-tuning adaptive immune responses during HIV-1 infection.  Additionally, we analyze immunological networks associated with immune control of HIV-1 and Zika virus using systems biology-based approaches.

Recognition and Media

Xu Yu is an elected member of the American Society for Clinical Investigation (ASCI), inducted in 2021. She received both the Claflin Distinguished Scholar Award and the Stephen Krane Excellence in Research Award for her work at Massachusetts General Hospital. She has also received the Clinical Scientist Development Award from the Doris Duke Charitable Foundation.

About

Xu Yu received an MD from China Medical University in Shenyang, China, and completed postdoctoral training in the AIDS Research Center at MGH.