The Walker Laboratory focuses on learning from patients to determine how the body fights back against viral infection using HIV as a highly relevant example, trying to uncover mechanisms by which it succeeds and, importantly, why it usually fails. They study blood samples from persons with chronic HIV infection as well as from elite controllers, persons who are able to control HIV infection to undetectable levels without the need for antiretroviral therapy (ART)
Dr. Walker is a recipient of the Doris Duke Distinguished Clinical Scientist Award, a member of the Association of American Physician, the National Academy of Medicine, and the American Academy of Arts and Sciences. He is also a fellow of the American Association for the Advancement of Science and American Academy of Microbiology, as well as the recipient of two NIH Merit Awards.
Dr. Walker received a BS in chemistry in 1980 from the University of Colorado, Boulder, also attending the Swiss Federal Technical Institute (ETH), and his MD from Case Western Reserve University. He completed his internship and residency in internal medicine at MGH and Harvard Medical School, followed by an internship in pathology and fellowship training in infectious disease at MGH and Harvard Medical School. He is a native of Boulder, Colorado, and is board-certified in both internal medicine and infectious disease.
David R Collins, Jonathan M Urbach, Zachary J Racenet, Umar Arshad, Karen A Power, Ruchi M Newman, Geetha H Mylvaganam, Ngoc L Ly, Xiaodong Lian, Anna Rull, Yelizaveta Rassadkina, Adrienne G Yanez, Michael J Peluso, Steven G Deeks, Francesc Vidal, Mathias Lichterfeld, Xu G Yu, Gaurav D Gaiha, Todd M Allen, Bruce D Walker
Immunity. S1074-7613(21)00337-X. 2021 Sep 2; doi: 10.1016/j.immuni.2021.08.007. PubMed
Clayton, K. L., D. R. Collins, J. Lengieza, M. Ghebremichael, F. Dotiwala, J. Lieberman and B. D. Walker.
Nat Immunol 2018; 19(5): 475-486. PMCID: PMC6025741
Jiang C , Lian X, Gao C, Sun X, Einkauf B, Chevalier JM, Chen S, Hua S, Rhee B, Chang K, Blackmer JE, Osborn M, Peluso MJ, Hoh R, Somsouk M, Milush J, Bertagnoll LN, Sweet SE, Varriale JA, Burbelo PD, Chun TE, Laird GM, Serrao E, Engelman AN, Carrington M, Siliciano RF, Siliciano JM, Deeks SG, Walker BD, Lichterfeld M, Yu X.
Nature. 2020;585(7824):261-7
Gaiha, G., E. J. Rossin, J. Urbach, C. Landeros, D. R. Collins, C. Nwonu, I. Muzinghi, M. N. Anahtar, M. Waring, A. Piechocka-Trocha, M. Waring, D. Worrall, M. S. Ghebremichael, R. M. Newman, K. A. Power, T. M. Allen, J. Chodosh and B. D. Walker.
Science, 2019. 364(6439):480-4
Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H, Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N, Walker BD.
Nat Genet. 2017;49(2):193-203 PMCID: PMC5511375
Ndhlovu, Z., S. W. Kazer, T. Nkosi, F. Ogunshola, D. M. Muema, G. Anmole, S. A. Swann, A. Moodley, K. Dong, T. Reddy, M. A. Brockman, A. K. Shalek, T. Ndung'u and B. D. Walker.
Science Translational Medicine. 2019;11(493)
Pereyra F, Jia X, McLaren PJ, Telenti A, De Bakker P, Walker BD et al.
Science 2010 Dec 10; 330(6010):1551-1557. PubMed PMID: 21051598
Day C.L., Kaufmann D.E., Kiepiela P., Brown JA., Moodley ES., Reddy S., Mackey EW., Miller J.D., Leslie A.J., DePierres C., Mncube Z., Duraiswamy J., Zhu B., Eichbaum Q., Altfeld M., Wherry E.J., Coovadia H.M., Goulder P.J., Klenerman P., Ahmed R., Freeman GJ., Walker B.D.
Nature. 2006 Sep 21; 443(7109):350-4. PubMed PMID 16921384
Sophia Cheever
Research Technician I
David Collins
Research Fellow
Julia Hitschfel
Graduate Research Assistant
Xiaolong Li
Research Fellow
Funsho Ogunshola
Research Fellow
Mpho Olatotse
Research Technician I
Alicja Piechocka-Trocha
Senior Lab Manager
Aaron Shulkin
Research Technician II
Nishant Singh
Research Fellow
Jonathan Urbach
BioInformatics Specialist I
Liza Vecchiarello
Research Technician I
Lucy Walters
Research Fellow
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